2-REAL-GUTS - innovation in intestinal models for food research

Introduction to the project

From research over the last two decades it has become increasingly apparent that the intestine plays a crucial role in sustaining general health in human. Several companies have expressed a need for relevant in vitro research models for the intestine, enabling the possibility to use these models for the Research and Development of their products.

2-REAL-GUTS entails the development and implementation of two innovative intestinal in vitro models. These models, which are derived from fundamental research, can play an important role in the safety and efficacy evaluation of food ingredients. With the development and especially the implantation of these in vitro models the project will contribute to the reduction of the use of animals in the safety evaluation of food additives and ingredients.

In collaboration with TNO, Immuno Valley will play a role in the dissemination of the project results. The research output of the project will be made available to other parties by means of symposia, publications and spin-off commercial applications. 

Project Aim

The study aims to further develop, optimize and implement the culture models to increase the biological relevance and simultaneously increase applicability of the models, contributing to the adoption of the systems by industry. 

The Research Group for Life Sciences & Chemistry has obtained SIA RAAK-PRO funding for the development and implementation of two innovative intestinal in vitro models.

Facts & Figures

  • Funding: SIA RAAK-PRO grant
  • Budget: 700.000 Euro awarded
  • Project start: October 2015
  • Estimated project end: October 2019

Project Partners:

Hogeschool Utrecht, Fontys Hogescholen, Hubrecht Organoid Technology Foundation, Utrecht University, Wageningen University Research Centre, TNO, Immuno Valley